Potential role of corneal epithelial cell-derived exosomes in corneal wound healing and neovascularization
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چکیده
منابع مشابه
Potential role of corneal epithelial cell-derived exosomes in corneal wound healing and neovascularization
Specific factors from the corneal epithelium underlying the stimulation of stromal fibrosis and myofibroblast formation in corneal wound healing have not been fully elucidated. Given that exosomes are known to transfer bioactive molecules among cells and play crucial roles in wound healing, angiogenesis, and cancer, we hypothesized that corneal epithelial cell-derived exosomes may gain access t...
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The corneal surface is, without question, the most specialised 123 mm2* of the body's surface. It forms an integral part of the ocular surface with which it shares several anatomical and physiological attributes. Like the rest ofthe body surface, it is in a state of constant 'healing'. Squamous epithelial cells are continually shed into the tear pool and simultaneously replenished by cells movi...
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BACKGROUND/AIMS During the healing of corneal epithelial wounds with limbal involvement, conjunctival epithelium often migrates across the denuded limbus to cover the corneal surface. It is believed that, over a period of time, conjunctival epithelium covering the cornea assumes characteristics of corneal epithelium by a process referred to as conjunctival transdifferentiation. The purpose of t...
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Corneal tissue regeneration is of crucial importance for maintaining normal vision. We aimed to isolate and cultivate human corneal stroma-derived mesenchymal stem-like cells (CSMSCs) from the central part of cadaver corneas and study their phenotype, multipotency, role in immunity and wound healing. The isolated cells grew as monolayers in vitro, expressed mesenchymal- and stemness-related sur...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/srep40548